Asbestos Malignancies Pulmonary Toxicity And The Mesothelioma Menace
| By: Mont Wrobleski To determine whether asbestos causes apoptosis in vivo, rats received a single intratracheal instillation of amosite (5 mg) or normal saline solution, and apoptosis in epithelial cells in the bronchoalveolar duct regions was assessed by TUNEL staining. One week after exposure, amosite asbestos caused a 3-fold increase in the percentage of apoptotic cells in the bronchoalveolar duct regions as compared with control (control, 2.1% ± 0.35%; asbestos, 7.61% ± 0.15%; N = 3). However, by 4 weeks the number of apoptotic cells was similar to control. We conclude that asbestos-induced pulmonary toxicity may partly be caused by apoptosis in the lung epithelium that is mediated by iron-catalyzed ROS and caspase 3 activation.” Another interesting study is called, “Comparative Proliferative and Histopathologic Changes in Rat Lungs after Inhalation of Chrysotile or Crocidolite Asbestos” by Kelly A. BéruBéa, Timothy R. Quinlana, Gerald Moultona, David Hemenwayb, Patrick O'Shaughnessyb, Pamela Vacekc and Brooke T. Mossmana - Toxicology and Applied Pharmacology - Volume 137, Issue 1, March 1996, Pages 67-74. Here is an excerpt: “Patterns of cell proliferation in lung and pleura and development of histopathologic lesions were studied in lungs from Fischer 344 rats after inhalation exposure to chrysotile or crocidolite asbestos at average airborne concentrations of approximately 8 mg/m3air for 5 and 20 days and after 20 days of exposure followed by an additional 20 days in room air (20 + 20 days). To assess cell proliferation rats were injected with 5-bromo-2'-deoxyuridine (BrdU) at various time points after initiation of exposure to asbestos. Image analysis was used to quantitate the effects of chrysotile and crocidolite on BrdU labeling indices in the following lung compartments: (1) interstitium, (2) alveolar duct region, (3) bronchial epithelium, and (4) visceral mesothelium. With the exception of mesothelium, which exhibited significant increases in BrdU incorporation in rats exposed to crocidolite at 20 + 20 days, asbestos-induced elevations in BrdU uptake in other compartments were transient with labeling comparable to sham controls at later time points. Histopathology of rat lungs revealed fibrotic lesions of a greater extent and severity at 20 days in rats exposed to crocidolite, but fibrosis occurred in both asbestos-exposed groups after an additional 20 days in clean air (20 + 20). Quantification of fiber burden in rat lung after inhalation of comparable airborne concentrations of either fiber type demonstrated that inhalation of crocidolite asbestos led to a higher fiber retention when compared to chrysotile asbestos. Our results indicate that chrysotile and crocidolite asbestos induce different patterns of cell proliferation in lung and pleural cells. The protracted increases in BrdU labeling of mesothelial cells by crocidolite may reflect increased retention of fibers and/or inherent differences between types of asbestos.” About the Author: Monty Wrobleski is the author of this article on Texas Mesothelioma Attorney, Mesothelio ma Lawyer Texas Related Articles A Powerful Solution In Ovarian Cysts Treatment C ncer de mama tambi n da a hombres Are Sunscreens Really Necessary For Everyone What is Breast Cancer An Successful Strategy to Fight Most cancers Employing Organic Foodstuff As Your Medicine Prostate Cancer Life Expectancy Early Breast Cancer Treatment Options that May Save Your Life The Right Way To Take Care Of Your Skin Colon cancer is the most usual cause of cancer demise Tips And Tricks On Prostate Cancer Statistics Leukemia Cure Survival Rates Of Patients With Leukemia Healthy Prostates Need Supplements A 10 yr Force To Put The Brakes On Breast Cancer Exercise for Immunity Should Preventive Mastectomy Be Among Allowed Treatments For Breast Cancer Want To Get The Best Gas Mileage Look No Further |